Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi

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Title
Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi
Author(s)
Seung Ho Lee; Hyae Kyeong Kim; Jeong Min Seo; Hyun Mi Kang; Jong Han Kim; Kwang Hee Son; H S Lee; Byoung-Mog Kwon; J H Shin; Y W Seo
Bibliographic Citation
Journal of Organic Chemistry, vol. 67, no. 22, pp. 7670-7675
Publication Year
2002
Abstract
Arteminolides B-D (2-4), new farnesyl protein transferase inhibitors, were isolated together with a known arteminolide A (1) and new regioisomers (5-7) of the compounds from the aerial parts of Artemisia argyi. Structures of these compounds were elucidated by spectroscopic methods and chemical conversion. Arteminolides inhibited the farnesyl protein transferase with IC50 values of 0.7-1/ μM, while the regioisomers 5-7 were inactive. In addition, it was proved that the exocyclic double bond of sesquiterpene lactone did not affect the inhibitory activity of arteminolide. The effects of compound 2 on H-Ras processing and cellular growth in H-ras-transformed cells were also evaluated.
ISSN
0022-3263
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jo020299z
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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