Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi
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- Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi
- Seung Ho Lee; Hyae Kyeong Kim; Jeong Min Seo; Hyun Mi Kang; Jong Han Kim; Kwang Hee Son; H S Lee; Byoung-Mog Kwon; J H Shin; Y W Seo
- Bibliographic Citation
- Journal of Organic Chemistry, vol. 67, no. 22, pp. 7670-7675
- Publication Year
- Arteminolides B-D (2-4), new farnesyl protein transferase inhibitors, were isolated together with a known arteminolide A (1) and new regioisomers (5-7) of the compounds from the aerial parts of Artemisia argyi. Structures of these compounds were elucidated by spectroscopic methods and chemical conversion. Arteminolides inhibited the farnesyl protein transferase with IC50 values of 0.7-1/ μM, while the regioisomers 5-7 were inactive. In addition, it was proved that the exocyclic double bond of sesquiterpene lactone did not affect the inhibitory activity of arteminolide. The effects of compound 2 on H-Ras processing and cellular growth in H-ras-transformed cells were also evaluated.
- Amer Chem Soc
- Appears in Collections:
- Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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