Cytotoxic sesquiterpene lactones form Carpesium abrotanoides

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Title
Cytotoxic sesquiterpene lactones form Carpesium abrotanoides
Author(s)
J S Lee; Byung Sun Min; Sang Myung Lee; M K Na; Byoung-Mog Kwon; C O Lee; Y H Kim; K H Bae
Bibliographic Citation
Planta Medica, vol. 68, no. 7, pp. 745-747
Publication Year
2002
Abstract
Eight sesquiterpene lactones, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 μM) against all tumor call lines tested. Among these compounds, 4α, 5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 μM) comparable to that of cisplatin.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2002-33789
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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