GSH2, a gene encoding γ-glutamylcysteine synthetase in the methylotrophic yeast Hansenula polymorpha

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dc.contributor.authorV M Ubiyvovk-
dc.contributor.authorT Y Nazarko-
dc.contributor.authorO G Stasyk-
dc.contributor.authorMin Jeong Sohn-
dc.contributor.authorHyun Ah Kang-
dc.contributor.authorA A Sibirny-
dc.date.accessioned2017-04-19T08:59:26Z-
dc.date.available2017-04-19T08:59:26Z-
dc.date.issued2002-
dc.identifier.issn1567-1356-
dc.identifier.uri10.1016/S1567-1356(02)00111-3ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/5974-
dc.description.abstractThe GSH2 gene, encoding Hansenula polymorpha γ-glutamylcysteine synthetase, was cloned by functional complementation of a glutathione (GSH)-deficient gsh2 mutant of H. polymorpha. The gene was isolated as a 4.3-kb XbaI fragment that was capable of restoring GSH synthesis, heavy-metal resistance and cell proliferation when introduced into gsh2 mutant cells. It possesses 53% identical and 69% similar amino acids compared with the Candida albicans homologue (Gcs1p). In comparison to the Saccharomyces cerevisiae homologue (Gsh1p), it possesses 47% identical and 61% similar amino acids. The GSH2 sequence appears in the GenBank database under accession No. AF435121.-
dc.publisherOxford Univ Press-
dc.titleGSH2, a gene encoding γ-glutamylcysteine synthetase in the methylotrophic yeast Hansenula polymorpha-
dc.title.alternativeGSH2, a gene encoding γ-glutamylcysteine synthetase in the methylotrophic yeast Hansenula polymorpha-
dc.typeArticle-
dc.citation.titleFEMS Yeast Research-
dc.citation.number3-
dc.citation.endPage332-
dc.citation.startPage327-
dc.citation.volume2-
dc.contributor.affiliatedAuthorMin Jeong Sohn-
dc.contributor.affiliatedAuthorHyun Ah Kang-
dc.contributor.alternativeNameUbiyvovk-
dc.contributor.alternativeNameNazarko-
dc.contributor.alternativeNameStasyk-
dc.contributor.alternativeName손민정-
dc.contributor.alternativeName강현아-
dc.contributor.alternativeNameSibirny-
dc.identifier.bibliographicCitationFEMS Yeast Research, vol. 2, no. 3, pp. 327-332-
dc.identifier.doi10.1016/S1567-1356(02)00111-3-
dc.subject.keywordγ-Glutamylcysteine synthetase-
dc.subject.keywordGlutathione biosynthesis-
dc.subject.keywordHansenula polymorpha-
dc.subject.keywordMethylotrophic yeast-
dc.subject.localγ-Glutamylcysteine synthetase-
dc.subject.localGlutathione biosynthesis-
dc.subject.localHansenulapolymorpha-
dc.subject.localhansenula polymorpha-
dc.subject.localHansenula polymorpha-
dc.subject.localHansenula polymorpha (Pichia angusta)-
dc.subject.localMethylotrophic yeast-
dc.subject.localmethylotrophic yeast-
dc.description.journalClassY-
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