Anti-human immunodeficiency virus-type 1 activity of constituents from Juglans mandshurica

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Title
Anti-human immunodeficiency virus-type 1 activity of constituents from Juglans mandshurica
Author(s)
Byung Sun Min; Hyeong Kyu Lee; Sang Myung Lee; Young Ho Kim; K H Bae; T Otake; N Nakamura; M Hattori
Bibliographic Citation
Archives of Pharmacal Research, vol. 25, no. 4, pp. 441-445
Publication Year
2002
Abstract
Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration (IC100) value of 25 μg/ml and maximum cytotoxic concentration (CC100) value of above 100 μg/ml. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.
Keyword
anti-HIV activityjuglans mandshuricaMT-4 cellstaxifolin
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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