Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones

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Title
Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones
Author(s)
N H Nam; Y Kim; Y J You; Dong Ho Hong; Hwan Mook Kim; B Z Ahn
Bibliographic Citation
Archives of Pharmacal Research, vol. 25, no. 5, pp. 600-607
Publication Year
2002
Abstract
Two series of 2,3-diarylcyclopent-2-ene-1-ones including 2-aryl-3-(2,5-dihydroxyphenyl)cyclopent-2-ene-1-ones (2a-2f) and 3-aryl-2-(3′,4′,5′-trimethoxyphenyl)cyclopent-2-ene-1-one (3a-3j) were synthesized and evaluated for the cytotoxicity against three tumor cell lines; B16F10, HCT116 and A431. It was found that the 3,4,5-trimethoxy substituent was optimal for the bio-activity of compounds in series 2. Meanwhile, compounds in series 3 exhibited the most potent cytotoxicity with 3-aryl ring being 4-methoxyphenyl (compound 3f), (3-hydroxy-4-methoxy)phenyl (compound 3e), or (3-amino-4-methoxy)phenyl (compound 3j).
Keyword
2,3-Diarylcyclopent-2-ene-1-onesantitumor activitycytotoxicity
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976928
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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