Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors

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Title
Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors
Author(s)
L Toma; M P Giovannoni; C Vergelli; V D Piaz; Byoung-Mog Kwon; Young Kook Kim; A Gelain; D Barlocco
Bibliographic Citation
Archiv der Pharmazie, vol. 335, no. 11, pp. 563-566
Publication Year
2002
Abstract
A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5,6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.
Keyword
5,6-Diphenylpyridazine derivativesACAT inhibitorsAcyl-CoA:cholesterol acyltransferase (ACAT)Hypercholesterolemia
ISSN
0365-6233
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ardp.200290010
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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