Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors
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- Title
- Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors
- Author(s)
- L Toma; M P Giovannoni; C Vergelli; V D Piaz; Byoung-Mog Kwon; Young Kook Kim; A Gelain; D Barlocco
- Bibliographic Citation
- Archiv der Pharmazie, vol. 335, no. 11, pp. 563-566
- Publication Year
- 2002
- Abstract
- A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5,6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.
- Keyword
- 5,6-Diphenylpyridazine derivativesACAT inhibitorsAcyl-CoA:cholesterol acyltransferase (ACAT)Hypercholesterolemia
- ISSN
- 0365-6233
- Publisher
- Wiley
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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