Inhibitory effect of TNF-α and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum

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Title
Inhibitory effect of TNF-α and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum
Author(s)
X F Cai; G Shen; N T Dat; O H Kang; J A Kim; Y M Lee; Jung Joon Lee; Y H Kim
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 51, no. 5, pp. 605-607
Publication Year
2003
Abstract
A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH2Cl2 fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-α-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-α secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.
Keyword
acanthopanax koreanumditerpenoidIL-8inhibitory effectTNF-α
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.51.605
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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