Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells

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Title
Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells
Author(s)
Jong Soon Kang; Song Kyu Park; Kyu-Hwan Yang; Hwan Mook Kim
Bibliographic Citation
FEBS Letters, vol. 550, no. 1, pp. 89-93
Publication Year
2003
Abstract
Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-α-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-α-induced DNA binding of NF-κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.
Keyword
e-selectinICAM-1NF-κB/RelsilymarinVCAM-1
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/S0014-5793(03)00827-5
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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