Cited 42 time in
- Title
- Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells
- Author(s)
- Jong Soon Kang; Song Kyu Park; Kyu-Hwan Yang; Hwan Mook Kim
- Bibliographic Citation
- FEBS Letters, vol. 550, no. 1, pp. 89-93
- Publication Year
- 2003
- Abstract
- Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-α-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-α-induced DNA binding of NF-κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.
- Keyword
- ICAM-1NF-κB/Rele-selectinsilymarinVCAM-1
- ISSN
- 0014-5793
- Publisher
- Wiley
- DOI
- http://dx.doi.org/10.1016/S0014-5793(03)00827-5
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
- Files in This Item:
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.