Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma

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Title
Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma
Author(s)
Sang Myung Lee; Jung Hee Kim; Y Zhang; Ren Bo An; Byung Sun Min; Hyouk Joung; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 26, no. 6, pp. 463-465
Publication Year
2003
Abstract
Four protostane-type triterpenes, alisol B 23-acetate (1a), alisol C 23-acetate (2a), alisol B (3a), and alisol A 24-acetate (4a), were isolated from the rhizome of Alismatis plantago-aquatica L. var. orientale Samuelson (Alismataceae) and eleven protostane derivatives (compounds 1-11) were obtained by selective modification from alisol B 23-acetate (1a). These compounds were investigated for their anti-complement activity against the classical pathway of the complement system. Alisol B (3a) and alisol A 24-acetate (4a) exhibited anti-complement activity with IC50 values of 150 and 130 μM. Among the synthetic derivatives, the tetrahydroxylated protostane triterpene (9) showed moderate inhibitory activity with IC50 value of 97.1 μM. Introduction of an aldehyde group at C-23 (10; IC50 value, 47.7 μM) showed the most potent inhibitory effect on the complement system in vitro.
Keyword
Alismatis rhizomaAnti-complementary activityProtostane-type triterpene
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/bf02976863
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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