Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma

Cited 49 time in scopus
Metadata Downloads
Anti-complementary activity of protostane-type triterpenes from Alismatis rhizoma
Sang Myung Lee; Jung Hee Kim; Y Zhang; Ren Bo An; Byung Sun Min; Hyouk Joung; Hyeong Kyu Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 26, no. 6, pp. 463-465
Publication Year
Four protostane-type triterpenes, alisol B 23-acetate (1a), alisol C 23-acetate (2a), alisol B (3a), and alisol A 24-acetate (4a), were isolated from the rhizome of Alismatis plantago-aquatica L. var. orientale Samuelson (Alismataceae) and eleven protostane derivatives (compounds 1-11) were obtained by selective modification from alisol B 23-acetate (1a). These compounds were investigated for their anti-complement activity against the classical pathway of the complement system. Alisol B (3a) and alisol A 24-acetate (4a) exhibited anti-complement activity with IC50 values of 150 and 130 μM. Among the synthetic derivatives, the tetrahydroxylated protostane triterpene (9) showed moderate inhibitory activity with IC50 value of 97.1 μM. Introduction of an aldehyde group at C-23 (10; IC50 value, 47.7 μM) showed the most potent inhibitory effect on the complement system in vitro.
Alismatis rhizomaAnti-complementary activityProtostane-type triterpene
Pharmaceutical Soc Korea
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.