Lignans from Saururus chinensis inhibiting the transcription factor NF-κB

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Title
Lignans from Saururus chinensis inhibiting the transcription factor NF-κB
Author(s)
Bang Yeon Hwang; Jeong-Hyung Lee; Jeong Bum Nam; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Phytochemistry, vol. 64, no. 3, pp. 765-771
Publication Year
2003
Abstract
The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-κB reporter construct. All compounds except for (+)-saucernetin inhibited NF-κB dependent reporter gene expression with IC50 values of 2.5-16.9 μM.
Keyword
lignannuclear factor κBsaucerneol Dsaucerneol Esaururaceaesaururus chinensissesquineolignan
ISSN
0031-9422
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0031-9422(03)00391-1
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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