Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki

Cited 5 time in scopus
Metadata Downloads
Title
Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki
Author(s)
Mun Chual Rho; Mi Yeon Chung; Hye Young Song; Oh Eok Kwon; Seung Woong Lee; Jin Ah Baek; K H Jeune; Koanhoi Kim; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 26, no. 9, pp. 716-718
Publication Year
2003
Abstract
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 μg/mL.
Keyword
acyl-CoAcholesterol acyltransferasediospyros kakipheophorbide A-methyl ester
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02976679
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.