Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki
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- Title
- Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki
- Author(s)
- Mun Chual Rho; Mi Yeon Chung; Hye Young Song; Oh Eok Kwon; Seung Woong Lee; Jin Ah Baek; K H Jeune; Koanhoi Kim; Hyun Sun Lee; Young Kook Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 26, no. 9, pp. 716-718
- Publication Year
- 2003
- Abstract
- In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 μg/mL.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/BF02976679
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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