Dimerization of thyroglobulin in the endoplasmic reticulum = Thyroglobulin의 소포체내 dimerization

Cited 0 time in scopus
Metadata Downloads
Title
Dimerization of thyroglobulin in the endoplasmic reticulum = Thyroglobulin의 소포체내 dimerization
Author(s)
Kee Sun Shin; O Y Kwon
Bibliographic Citation
Korean Journal of Life Sciences, vol. 13, no. 3, pp. 248-251
Publication Year
2003
Abstract
The kinetics of dimerization of a newly synthesized thyroglobulin (Tg), the precursor protein in the manufacture of thyroid hormone, was investigated in the endoplasmic reticulum of thyrocytes FRTL-5 cell line. The folded monomeric Tg was first detectable in a conformationally unstable form, from the examination of lysates of pulse labeled cultured thyrocytes by denaturing and nondenaturing gel electrophoresis by 15 min after biosynthesis. The first dimeric Tg was formed by 30 min after; the monomer declined and the dimer progressively increased, and 40 min after remarkable dimeric Tg form was found. Finally, dimerization was complete at 60 min after.
Keyword
thyroglobulin (Tg)endoplasmic reticulum (ER)two-dimensional electrophoresis (2-DE)
ISSN
I000-0052
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.