Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

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Title
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola
Author(s)
H J Jung; Hyang Burm Lee; C H Lim; Chang-Jin Kim; H J Kwon
Bibliographic Citation
Bioorganic & Medicinal Chemistry, vol. 11, no. 22, pp. 4743-4747
Publication Year
2003
Abstract
Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.
ISSN
0968-0896
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/S0968-0896(03)00523-6
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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