Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor

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Title
Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor
Author(s)
S E Hwang; H M Im; D H Kim; H J Shin; D H Shin; J E Park; I H Jo; Chang-Jin Kim; J S Yoo; J M Kang; D Y Lim; S M Ahn-Jo; H J Kwon
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 13, no. 5, pp. 809-814
Publication Year
2003
Abstract
Beta-amyloid peptides from the proteolytic processing of Beta-amyloid precursor protein aggregates in the brain to form senile plaques, and their aggregation plays key role in pathogenensis of Alzheimer's disease. To isolate an active compound that has an Abeta aggregation inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit Abeta aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microoganism, KK565, showed a potent Abeta aggregation-inhibitory activity
Keyword
alzheimer's diseaseβ-amyloidstreptomyces sp.Aβ aggregation-inhibitor
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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