DC Field | Value | Language |
---|---|---|
dc.contributor.author | S E Hwang | - |
dc.contributor.author | H M Im | - |
dc.contributor.author | D H Kim | - |
dc.contributor.author | H J Shin | - |
dc.contributor.author | D H Shin | - |
dc.contributor.author | J E Park | - |
dc.contributor.author | I H Jo | - |
dc.contributor.author | Chang-Jin Kim | - |
dc.contributor.author | J S Yoo | - |
dc.contributor.author | J M Kang | - |
dc.contributor.author | D Y Lim | - |
dc.contributor.author | S M Ahn-Jo | - |
dc.contributor.author | H J Kwon | - |
dc.date.accessioned | 2017-04-19T09:00:28Z | - |
dc.date.available | 2017-04-19T09:00:28Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/6296 | - |
dc.description.abstract | Beta-amyloid peptides from the proteolytic processing of Beta-amyloid precursor protein aggregates in the brain to form senile plaques, and their aggregation plays key role in pathogenensis of Alzheimer's disease. To isolate an active compound that has an Abeta aggregation inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit Abeta aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microoganism, KK565, showed a potent Abeta aggregation-inhibitory activity | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor | - |
dc.title.alternative | Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor | - |
dc.type | Article | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 814 | - |
dc.citation.startPage | 809 | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Chang-Jin Kim | - |
dc.contributor.alternativeName | 황성은 | - |
dc.contributor.alternativeName | 임형민 | - |
dc.contributor.alternativeName | 김동훈 | - |
dc.contributor.alternativeName | 신현주 | - |
dc.contributor.alternativeName | 신동훈 | - |
dc.contributor.alternativeName | 박정은 | - |
dc.contributor.alternativeName | 조인호 | - |
dc.contributor.alternativeName | 김창진 | - |
dc.contributor.alternativeName | 유종신 | - |
dc.contributor.alternativeName | 강종민 | - |
dc.contributor.alternativeName | 임동열 | - |
dc.contributor.alternativeName | 안조상미 | - |
dc.contributor.alternativeName | 권호정 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, vol. 13, no. 5, pp. 809-814 | - |
dc.subject.keyword | alzheimer's disease | - |
dc.subject.keyword | β-amyloid | - |
dc.subject.keyword | streptomyces sp. | - |
dc.subject.keyword | Aβ aggregation-inhibitor | - |
dc.subject.local | alzheimer's disease | - |
dc.subject.local | Alzheimer’s disease (AD) | - |
dc.subject.local | Alzheimer’s disease | - |
dc.subject.local | Alzheimer's Disease | - |
dc.subject.local | Alzheimer disease | - |
dc.subject.local | Alzheimer's disease (AD) | - |
dc.subject.local | Alzheimer′s disease | - |
dc.subject.local | Alzheimer's disease | - |
dc.subject.local | beta-amyloid | - |
dc.subject.local | beta amyloid | - |
dc.subject.local | β-amyloids | - |
dc.subject.local | β-amyloid | - |
dc.subject.local | Streptomyces sp | - |
dc.subject.local | Streptomyces sp. | - |
dc.subject.local | streptomyces sp. | - |
dc.subject.local | Aβ aggregation-inhibitor | - |
dc.description.journalClass | Y | - |
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