Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor

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dc.contributor.authorS E Hwang-
dc.contributor.authorH M Im-
dc.contributor.authorD H Kim-
dc.contributor.authorH J Shin-
dc.contributor.authorD H Shin-
dc.contributor.authorJ E Park-
dc.contributor.authorI H Jo-
dc.contributor.authorChang-Jin Kim-
dc.contributor.authorJ S Yoo-
dc.contributor.authorJ M Kang-
dc.contributor.authorD Y Lim-
dc.contributor.authorS M Ahn-Jo-
dc.contributor.authorH J Kwon-
dc.date.accessioned2017-04-19T09:00:28Z-
dc.date.available2017-04-19T09:00:28Z-
dc.date.issued2003-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/6296-
dc.description.abstractBeta-amyloid peptides from the proteolytic processing of Beta-amyloid precursor protein aggregates in the brain to form senile plaques, and their aggregation plays key role in pathogenensis of Alzheimer's disease. To isolate an active compound that has an Abeta aggregation inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit Abeta aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microoganism, KK565, showed a potent Abeta aggregation-inhibitory activity-
dc.publisherSouth Korea-
dc.titleIsolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor-
dc.title.alternativeIsolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number5-
dc.citation.endPage814-
dc.citation.startPage809-
dc.citation.volume13-
dc.contributor.affiliatedAuthorChang-Jin Kim-
dc.contributor.alternativeName황성은-
dc.contributor.alternativeName임형민-
dc.contributor.alternativeName김동훈-
dc.contributor.alternativeName신현주-
dc.contributor.alternativeName신동훈-
dc.contributor.alternativeName박정은-
dc.contributor.alternativeName조인호-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeName유종신-
dc.contributor.alternativeName강종민-
dc.contributor.alternativeName임동열-
dc.contributor.alternativeName안조상미-
dc.contributor.alternativeName권호정-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 13, no. 5, pp. 809-814-
dc.subject.keywordalzheimer's disease-
dc.subject.keywordβ-amyloid-
dc.subject.keywordstreptomyces sp.-
dc.subject.keywordAβ aggregation-inhibitor-
dc.subject.localalzheimer's disease-
dc.subject.localAlzheimer’s disease-
dc.subject.localβ-amyloid-
dc.subject.localstreptomyces sp.-
dc.subject.localStreptomyces sp.-
dc.subject.localAβ aggregation-inhibitor-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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