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- Title
- Isolation of Streptomyces sp. KK565 as a producer of β-amyloid aggregation inhibitor
- Author(s)
- S E Hwang; H M Im; D H Kim; H J Shin; D H Shin; J E Park; I H Jo; Chang-Jin Kim; J S Yoo; J M Kang; D Y Lim; S M Ahn-Jo; H J Kwon
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 13, no. 5, pp. 809-814
- Publication Year
- 2003
- Abstract
- Beta-amyloid peptides from the proteolytic processing of Beta-amyloid precursor protein aggregates in the brain to form senile plaques, and their aggregation plays key role in pathogenensis of Alzheimer's disease. To isolate an active compound that has an Abeta aggregation inhibitory activity, 2,000 microbial metabolite libraries were screened based on their ability to inhibit Abeta aggregation by using both Congo red and thioflavin T assays. As a result, a water-soluble fraction of a soil microoganism, KK565, showed a potent Abeta aggregation-inhibitory activity
- Keyword
- alzheimer's diseaseβ-amyloidstreptomyces sp.Aβ aggregation-inhibitor
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
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