Fine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9

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Title
Fine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9
Author(s)
K I Cho; Jeong Woong Lee; K S Kim; E J Lee; J G Suh; H J Lee; H T Kim; S H Hong; W H Chung; Kyu Tae Chang; Byung Hwa Hyun; Y S Oh; Z Y Ryoo
Bibliographic Citation
Comparative Medicine, vol. 53, no. 6, pp. 642-648
Publication Year
2003
Abstract
Circling mice manifest profound deafness, head-tossing, and bi-directional circling behavior, which they inherit in autosomal recessive manner. Histologic examination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. A genetic linkage map was constructed for an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mit116/D9Mit15 and D9Mit38 on mouse chromosome (Chr) 9. Estimated distances between cir and D9Mit116, and between cir and D9Mit38 were 0.70 ± 0.40 and 0.23 ± 0.23 cM, respectively. Order of the markers was defined as follows: centromere - D9Mit182 - D9Mit51/D9Mit79/D9Mit310 -D9Mit212/D9Mit184 - D9Mit116/D9Mit15 - cir - D9Mit38 - D9Mit20 - D9Mit243 - D9Mit16 - D9Mit55/D9Mit125 - D9Mit281. On the basis of genetic mapping, we constructed a yeast artificial chromosome (YAC) contig across the cir region. The cir gene is located between the lactotransferrin (ltf) and microtubule-associated protein (map4) genes. The distal portion of mouse Chr 9 encompassing the cir region is homologous with human chromosome 3p21, which contains the Deafness, form B: Autosomal Recessive Deafness (DFNB6) locus. Therefore, the circling mouse is a potential animal model for DFNB6 deafness in humans.
ISSN
1532-0820
Publisher
Amer Assoc Laboratory Animal Science
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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