Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties

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Title
Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties
Author(s)
Jong Pyung Kim; Byoung Kwon Kim; Bong Sik Yun; In Ja Ryoo; Choong Hwan Lee; In Kyung Lee; Won Gon Kim; Sangku Lee; Y R Pyun; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 56, no. 12, pp. 993-999
Publication Year
2003
Abstract
New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nm and MIC value of 0.9 μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.56.993
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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