Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties

Cited 14 time in scopus
Metadata Downloads
Title
Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties
Author(s)
Jong Pyung Kim; Byoung Kwon Kim; Bong Sik Yun; In Ja Ryoo; Choong Hwan Lee; In Kyung Lee; Won Gon KimSangku Lee; Y R Pyun; Ick Dong Yoo
Bibliographic Citation
Journal of Antibiotics, vol. 56, no. 12, pp. 993-999
Publication Year
2003
Abstract
New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nm and MIC value of 0.9 μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.7164/antibiotics.56.993
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.