Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties
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- Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties
- Jong Pyung Kim; Byoung Kwon Kim; Bong Sik Yun; In Ja Ryoo; Choong Hwan Lee; In Kyung Lee; Won Gon Kim; Sangku Lee; Y R Pyun; Ick Dong Yoo
- Bibliographic Citation
- Journal of Antibiotics, vol. 56, no. 12, pp. 993-999
- Publication Year
- New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nm and MIC value of 0.9 μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.
- Springer-Nature Pub Group
- Appears in Collections:
- Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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