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- Title
- Phenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet
- Author(s)
- B H Kim; Young Suk Won; E Y Kim; M J Yoon; K T Nam; Goo Taeg Oh; D Y Kim
- Bibliographic Citation
- Journal of Veterinary Science, vol. 4, no. 3, pp. 239-244
- Publication Year
- 2003
- Abstract
- Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.
- Keyword
- PhenotypePPARalpha-/- miceC57BL/6Nx129/Svhigh fat diet
- ISSN
- I000-0131
- Publisher
- Korea Soc-Assoc-Inst
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
- Files in This Item:
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