Four weeks repeated toxicity study of 2-omega-Benzoylcinnamaldehyde(CB-PH) by oral administration in sprague-dawley rats = 랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험

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Title
Four weeks repeated toxicity study of 2-omega-Benzoylcinnamaldehyde(CB-PH) by oral administration in sprague-dawley rats = 랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험
Author(s)
H M Jo; N W Seong; J H Che; K D Park; K T Nam; W S Cho; B S Han; K H Yang; B H Kim; K K Lee; Hyoung-Chin Kim; Byoung-Mog Kwon; Y S Park; D D Jang
Bibliographic Citation
Journal of Toxicology and Pubic Health, vol. 19, no. 4, pp. 259-266
Publication Year
2003
Abstract
Although Cinnamon has been widely used for the food and biophamacy in the world,it's toxicity was not screened completely. Major component of cinnamon is CB-OH and CB-PH. CB-PH has been reported to have antimutagenic effect. To investigate the toxicity of 2-o-Benzoylcinnama-ldehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeateddose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PHtreated group showed no significant toxicological findings with body weights, organ weights, hemato-logical and histopathological findings. Therefore, these data indicated that the maximum tolerateddose of CB-PH was 2000 mg above/kg/day in the rats.
Keyword
CB-PHrepeated dose toxicityrats
ISSN
I000-0084
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
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