Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction
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- Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction
- Y H Choi; H I Kim; J K Seong; Dae Yeul Yu; H S Cho; M O Lee; J M Lee; Y H Ahn; S J Kim; J H Park
- Bibliographic Citation
- FEBS Letters, vol. 557, no. 1, pp. 73-80
- Publication Year
- Ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein-protein interaction.
- Hepatitis B virus X protein; Peroxisome proliferator-activated receptor γ; Protein-protein interaction; Transactivation
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- 1. Journal Articles > Journal Articles
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