New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng

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Title
New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng
Author(s)
Seung Woong Lee; K H Kim; Mun Chual Rho; Mi Yeon Chung; Y H Kim; Sangku Lee; Hyun Sun Lee; Young Kook Kim
Bibliographic Citation
Planta Medica, vol. 70, no. 3, pp. 197-200
Publication Year
2004
Abstract
The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one (2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC50 values of 9 μg/mL (1) and 32 μg/ml (2) were obtained.
Keyword
AraliaceaeDiacylglycerol acyltransferase (DGAT)Panax ginsengPolyacetylenesStructure elucidation
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-815534
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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