Inhibitory activity of diarylheptanoids on farnesyl protein transferase

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Title
Inhibitory activity of diarylheptanoids on farnesyl protein transferase
Author(s)
Hyun Mi Kang; Kwang Hee Son; D C Yang; Dong Cho Han; Jong Han Kim; N I Baek; Byoung-Mog Kwon
Bibliographic Citation
Natural Product Research, vol. 18, no. 4, pp. 295-299
Publication Year
2004
Abstract
Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and a new cyclic diarylheptanoid (6) and a known Compound 7 were isolated from fruits of Alnus japonica Steud. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FPTase) with an IC50 of 29-50 μM. The other compounds very mildly inhibited FPTase, therefore, the inhibitory activity on FPTase very much depends on the structure of diarylheptanoids.
Keyword
Alnus japonicaCurcuma longaDiarylheptanoidsFarnesyl protein transferase
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786410310001620691
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
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