Relationship between flavonoid structure and inhibition of farnesyl protein transferase

Cited 24 time in scopus
Metadata Downloads
Title
Relationship between flavonoid structure and inhibition of farnesyl protein transferase
Author(s)
Hyun Mi Kang; Jong Han Kim; Mi Young Lee; Kwang Hee Son; D C Yang; N I Baek; Byoung-Mog Kwon
Bibliographic Citation
Natural Product Research, vol. 18, no. 4, pp. 349-356
Publication Year
2004
Abstract
Flavonoids are well-known phytochemicals that are produced by various plants in high quantities. The chemopreventive activity of flavonoids is dependent on their structural features. The studies of structure-FPTase inhibitory activity indicated that the number, position and substitution of hydroxyl groups of the A and B rings of flavonoid, and unsaturation of the C2-C3 bond are important factors affecting inhibition on FPTase by flavonoids. A couple of flavonoids inhibited FPTase and also the growth of human tumor cell lines, especially butein, which strongly inhibited the growth of colon cancer cell line (HCT116). However, flavanones and flavanols did not inhibit FPTase nor the growth of tumor cells.
Keyword
cell proliferation assayfarnesyl protein transferaseflavonoidstructure-activity relationship
ISSN
1029-2349
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1080/14786410310001622022
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.