Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis

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Title
Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis
Author(s)
Woo Song Lee; Dae Woo Lee; Young Il Baek; So Jin An; Kyung Hyun Cho; Yang Kyu Choi; Hyoung-Chin KimHo Yong Park; K H Bae; Tae Sook Jeong
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 12, pp. 3109-3112
Publication Year
2004
Abstract
The sesquineolignan, saucerneol B (1), and dineolignans, manassantin A (2), and manassantin B (3), were isolated from the methanol extracts of Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds 1-3 inhibited hACAT-1 and hACAT-2 with IC50 values of 43.0 and 124.0μM for 1, of 39.0 and 8.0μM for 2, of 82.0μM and only 32% inhibition at 1mM for 3, respectively. The EtOAc-soluble fraction, which contained compounds 1-3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
Keyword
hACAT-1 and hACAT-2Hypocholesterolemic activityInhibitorLignansS. chinensis
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2004.04.023
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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