Effect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice

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Title
Effect of flavon extracted from Artemisia absinthium on collagen induced arthritis in mice
Author(s)
K M Choi; D H Hwang; K M Shin; Do Young Yoon; D S Kim
Bibliographic Citation
Korean Journal of Pedriatrics, vol. 47, no. 6, pp. 677-684
Publication Year
2004
Abstract
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-α in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-α in the splenocytes were tested. Results : Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-α levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon. Conclusion : With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production
Keyword
flavonartemisia absinthiumcollagen induced arthritisIL-10TNF-α
ISSN
I000-0172
Publisher
Korea Soc-Assoc-Inst
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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