Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones

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Title
Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
Author(s)
S H Jung; H S Lee; N S Kim; Hwan Mook Kim; M S Lee; D R Choi; J A Lee; Y H Chung; Eun Yi Moon; H S Hwang; S K Seong; D K Lee
Bibliographic Citation
Archives of Pharmacal Research, vol. 27, no. 5, pp. 478-484
Publication Year
2004
Abstract
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
Keyword
1-(1-Benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolonescytotoxicitysubstituent's effect
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02980119
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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