Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
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- Title
- Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones
- Author(s)
- S H Jung; H S Lee; N S Kim; Hwan Mook Kim; M S Lee; D R Choi; J A Lee; Y H Chung; Eun Yi Moon; H S Hwang; S K Seong; D K Lee
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 27, no. 5, pp. 478-484
- Publication Year
- 2004
- Abstract
- The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
- Keyword
- 1-(1-Benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolonescytotoxicitysubstituent's effect
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/BF02980119
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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