Anti-inflammatory effect of kamebakaurin in in vivo animal models

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Title
Anti-inflammatory effect of kamebakaurin in in vivo animal models
Author(s)
Jeong-Hyung Lee; J K Choi; M S Noh; Bang Yeon Hwang; Young-Soo Hong; Jung Joon Lee
Bibliographic Citation
Planta Medica, vol. 70, no. 6, pp. 526-530
Publication Year
2004
Abstract
We have identified kamebakaurin as an inhibitor of NF-κB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-κB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expression of inflammatory NF-κB target genes such as iNOS, COX-2, and TNF-α, but also the production of PGE2 and TNF-α in LPS-stimulated RAW264.7 cells. Moreover, in an air pouch model of inflammation, it suppressed the recruitment of neutrophils, production of TNF-α as well as PGE2 in the pouch exudates induced by carrageenan. In addition, kamebakaurin dose-dependently suppressed the inflammation in an adjuvant arthritis model. Oral administration of 20 mg/kg kamebakaurin resulted in the 75% decrease of paw volume. Taken together, kamebakaurin, a specific inhibitor of DNA-binding activity of the p50 subunit, is a valuable candidate for the intervention in NF-κB-dependent pathological conditions such as inflammation.
Keyword
Adjuvant arthritisAir pouchAnti-inflammationDiterpeneKamebakaurinNF-κBp50
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-827152
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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