The p65 subunit of nuclear factor-κB is a molecular target for radiation sensitization of human squamous carcinoma cells

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Title
The p65 subunit of nuclear factor-κB is a molecular target for radiation sensitization of human squamous carcinoma cells
Author(s)
K M Kim; Y Zhang; Bo Yeon Kim; S J Jeong; S A Lee; G D Kim; A Dritschilo; M Jung
Bibliographic Citation
Molecular Cancer Therapeutics, vol. 3, no. 6, pp. 693-698
Publication Year
2004
Abstract
The transcription factor nuclear factor-κB (NF-κB) is activated in response to various stimuli including ionizing radiation. Disruption of NF-κB activation by mutant forms of the NF-κB inhibitor IκB-α or by proteasome inhibitors enhances both sensitivity to radiation and radiation-induced apoptosis. Human squamous carcinoma SCC-35 cells stably expressing a fragment (residues 1 to 84) of human p65 have been shown to exhibit down-regulation of both endogenous p65 mRNA and its protein. The mutant protein also inhibited radiation-induced NF-κB activation 6by preventing the proteolysis of IκB-α. This resulted in enhancement of cellular radiosensitivity and radiation-induced apoptosis. The NH2-terminal region of p65 is thus a potential molecular target for disruption of NF-κB activation and sensitization of tumors to radiotherapy.
ISSN
1535-7163
Publisher
Amer Assoc Cancer Research
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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