A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme

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Title
A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme
Author(s)
Eun Young Bae; Hyuncheol Oh; Won Keun Oh; Min Soo Kim; Beom Seok Kim; Bo Yeon Kim; C B Sohn; H Osada; Jong Seog Ahn
Bibliographic Citation
Planta Medica, vol. 70, no. 9, pp. 869-870
Publication Year
2004
Abstract
Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone (1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone (2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC50 value of 3.0 ± 0.2 μM.
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-827238
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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