Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds

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Title
Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds
Author(s)
N H Nam; D H Hong; Y J You; Y Kim; S C Bang; Hwan Mook Kim; B Z Ahn
Bibliographic Citation
Archives of Pharmacal Research, vol. 27, no. 6, pp. 581-588
Publication Year
2004
Abstract
A series of 2, 5-dihydroxychalcones and related compounds were synthesized, and their cytotoxicities against tumor cell lines and human umbilical venous endothelial cells (HUVEC) evaluated. It was found that chalcones, with electron-withdrawing substituents on an A ring, exhibited significant cytotoxicities. Among the synthesized compounds, 2′-chloro-2, 5-dihydroxychalcone (9) was most potent, with an IC50 value as low as 0.31 μg/mL. This compound also exhibited a significant cytotoxic selectivity toward HUVEC.
Keyword
chalconecytotoxicitystructure-activity relationship
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02980153
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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