The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens

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Title
The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens
Author(s)
S H Hong; J S Kim; S Y Lee; Y H In; S S Choi; Jeong Keun Rhi; Chang Hoon Kim; Haeyoung Jeong; Cheol-Goo Hur; J J Kim
Bibliographic Citation
Nature Biotechnology, vol. 22, no. 10, pp. 1275-1281
Publication Year
2004
Abstract
The rumen represents the first section of a ruminant animal's stomach, where feed is collected and mixed with microorganisms for initial digestion. The major gas produced in the rumen is CO2 (65.5 mol%), yet the metabolic characteristics of capnophilic (CO2-loving) microorganisms are not well understood. Here we report the 2,314,078 base pair genome sequence of Mannheimia succiniciproducens MBEL55E, a recently isolated capnophilic Gram-negative bacterium from bovine rumen, and analyze its genome contents and metabolic characteristics. The metabolism of M. succiniciproducens was found to be well adapted to the oxygen-free rumen by using fumarate as a major electron acceptor. Genome-scale metabolic flux analysis indicated that CO2 is important for the carboxylation of phosphoenolpyruvate to oxaloacetate, which is converted to succinic acid by the reductive tricarboxylic acid cycle and menaquinone systems. This characteristic metabolism allows highly efficient production of succinic acid, an important four-carbon industrial chemical.
ISSN
0733-222X
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nbt1010
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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