식용 식물자원으로부터 활성물질의 탐색-X.: 능소화(Campsis grandiflora K. schum.)로부터 지질화합물의 분리 및 FPTase 저해 효과 측정

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Title
식용 식물자원으로부터 활성물질의 탐색-X.: 능소화(Campsis grandiflora K. schum.)로부터 지질화합물의 분리 및 FPTase 저해 효과 측정
Author(s)
D H Kim; M C Song; K M Han; M H Bang; Byoung-Mog Kwon; S H Kim; D K Kim; I S Chung; M H Park; N I Baek
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 47, no. 3, pp. 357-360
Publication Year
2004
Abstract
The flower of Campsis grandiflora K. Schum. was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. From the EtOAc fraction, four compounds were isolated through the repeated silica gel and ODS column chromatographies. From the result of physico-chemical data including NMR, MS and IR, the chemical structures of the compounds were determined as linolenic acid methyl ester, linoleic acid methyl ester, β-sitosterol and daucosterol. Daucosterol inhibited FPTase activity with IC50 values of 14±0.04 μM.
Keyword
campsis grandiflora K. Schum.linoleic acidlinolenic acidβ-sitosteroldaucosterolFPTase
ISSN
I000-0171
Publisher
Springer
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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