Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase

Cited 22 time in scopus
Metadata Downloads
Title
Enhancement of tyrosinase inhibition of the extract of Veratrum patulum using cellulase
Author(s)
Dong Hyun Kim; Jin Hee Kim; Seung Hwa Baek; J H Seo; Yung Hee Kho; Tae Kwang Oh; Choong Hwan Lee
Bibliographic Citation
Biotechnology and Bioengineering, vol. 87, no. 7, pp. 849-854
Publication Year
2004
Abstract
Inhibitors of melanin biosynthesis were screened by using three different methods. The extract of Veratrum patulum contains hydroxystilbene compounds that are potent tyrosinase inhibitors. We evaluated the enzyme inhibitory property on the mushroom tyrosinase of hydroxystilbene compounds including resveratrol, oxyresveratrol, and their analogs. Biotransformation using cellulase of the whole extract brought about an increase in the inhibitory activity of the products on mushroom tyrosinase. The enhancement of tyrosinase inhibition is supposed to increase the concentration of aglycon, which has superior inhibitory activity to its glycoside. Eventually, melanin biosynthesis was inhibited by the enhanced tyrosinase inhibitory activity of the extract. This result indicated that deglycosylation of stilbene compounds has exerted more effective inhibition on the enzyme than that of the unprocessed plant extract.
Keyword
BiotransformationCellulaseResveratrolTyrosinase inhibitorVeratrum patulum
ISSN
0006-3592
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/bit.20189
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.