Identification of the Vibrio vulnificus cadC and evaluation of its role in acid tolerance

Cited 0 time in scopus
Metadata Downloads
Title
Identification of the Vibrio vulnificus cadC and evaluation of its role in acid tolerance
Author(s)
J E Rhee; H M Ju; U Park; Byoung Chul Park; S H Choi
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 14, no. 5, pp. 1093-1098
Publication Year
2004
Abstract
An open reading frame encoding CadC, consisting of 526 amino acids, was identified from the upstream region of the Vibrio vulnificus cadBA operon. The deduced amino acid sequences of the cadC were 22 to 78% similar to those reported from other Enterobacteriaceae. Functions of cadC gene on acid tolerance were assessed by comparing acid tolerances of V. vulnificus and its isogenic mutant, whose cadC gene was inactivated by allelic exchanges. The results demonstrated that the gene product of cadC contributes to acid tolerance of V. vulnificus, and that its contribution is dependent on prior exposure of cells to moderately acidic pH. The cellular level of cadB and cadA transcripts decreased in the cadC mutant, indicating that CadC exerts its effect on acid tolerance of V. vulnificus by enhancing the expression of cadBA in a pH-dependent manner ?
Keyword
acid tolerancecadCvibrio vulnificus
ISSN
1017-7825
Publisher
South Korea
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.