Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit

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Title
Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit
Author(s)
M Na; K Bae; S S Kang; Byung Sun Min; J K Yoo; Y Kamiryo; Y Senoo; S Yokoo; N Miwa
Bibliographic Citation
Phytotherapy Research, vol. 18, no. 9, pp. 737-741
Publication Year
2004
Abstract
The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 ± 3.8% at a concentration of 50 μg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 40% as a result of the continuous administration of 3 μg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.
Keyword
CombretaceaeOxidative stressSouthern blotsTelomere lengthTerminalia chebula
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.1529
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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