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- Title
- Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity
- Author(s)
- Byung Sun Min; H T T Huong; Jung Hee Kim; H J Jun; M K Na; N H Nam; Hyeong Kyu Lee; K Bae; S S Kang
- Bibliographic Citation
- Planta Medica, vol. 70, no. 12, pp. 1166-1169
- Publication Year
- 2004
- Abstract
- Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 μM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).
- Keyword
- Crataegus pinnatifidaCrataequinone ACrataequinone BFuro-1,2-naphthoquinoneICAM-1 inhibitory activityRosaceae
- ISSN
- 0032-0943
- Publisher
- Georg Thieme Verlag Kg
- DOI
- http://dx.doi.org/10.1055/s-2004-835846
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
- Files in This Item:
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