Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity

Cited 16 time in scopus
Metadata Downloads
Title
Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity
Author(s)
Byung Sun Min; H T T Huong; Jung Hee Kim; H J Jun; M K Na; N H Nam; Hyeong Kyu Lee; K Bae; S S Kang
Bibliographic Citation
Planta Medica, vol. 70, no. 12, pp. 1166-1169
Publication Year
2004
Abstract
Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 μM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).
Keyword
Crataegus pinnatifidaCrataequinone ACrataequinone BFuro-1,2-naphthoquinoneICAM-1 inhibitory activityRosaceae
ISSN
0032-0943
Publisher
Georg Thieme Verlag Kg
DOI
http://dx.doi.org/10.1055/s-2004-835846
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.