Open Access@KRIBBDivision of A.I. & Biomedical ResearchMicrobiome Convergence Research Center1. Journal Articles
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors
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- Title
- Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors
- Author(s)
- Tae Sook Jeong; Kyung Soon Kim; Hana Yu; Mi Jeong Kim; Kyung Hyun Cho; Yang Kyu Choi; Hyoung-Chin Kim; Ho Yong Park; Woo Song Lee
- Bibliographic Citation
- Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 2, pp. 385-388
- Publication Year
- 2005
- Abstract
- A series of saucerneol B derivatives 2a-i were prepared for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g showed more specificity of hACAT-1 than hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. A series of 2a-i were prepared from a lead compound, saucerneol B (1) for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g exhibited the high specificity of hACAT-1 than hACAT-2, whereas 2h and 2i showed very weak inhibitory activities in both hACAT-1 and hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
- Keyword
- ACAT inhibitor
- ISSN
- 0960-894X
- Publisher
- Elsevier
- Full Text Link
- http://dx.doi.org/10.1016/j.bmcl.2004.10.066
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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