Antidiabetic effects of extracts from Psidium guajava

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Title
Antidiabetic effects of extracts from Psidium guajava
Author(s)
Won Keun Oh; Chul Ho Lee; Myung Sun Lee; Eun Young Bae; C B Sohn; Hyuncheol Oh; Bo Yeon KimJong Seog Ahn
Bibliographic Citation
Journal of Ethnopharmacology, vol. 96, no. 3, pp. 411-415
Publication Year
2005
Abstract
During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Leprdb/Leprdb mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Leprdb/Leprdb mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Leprdb/Lepr db mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B.
Keyword
Blood glucoseLeprdb/Leprdb micePsidium guajavaPTP1BType 2 diabetes
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2004.09.041
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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