Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice

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Title
Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice
Author(s)
Ai-Guo Wang; H B Moon; Y H Lee; Seong Lan Yu; Hyun Jung Kwon; Y H Han; W Fang; T H Lee; K L Jang; S K Kim; Dae Yeul Yu; Dong Seok Lee
Bibliographic Citation
Experimental and Molecular Medicine, vol. 36, no. 6, pp. 588-593
Publication Year
2004
Abstract
Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are cytopathic to liver, three types of transgenic mice were established. The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S116I transgenic lineages remained largely histologically normal. However, the livers of the S99Q transgenic mice showed significant high level of cell dysplasia associated with the transgene expression in hepatocytes largely located around the central veins by in situ hybridization analysis. In conclusion, the mutant HCV core protein at S99Q may contribute to the progress of HCV induced liver disease.
Keyword
coredysplasiahepatitis C virustransgenic mice
ISSN
I000-0028
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/emm.2004.76
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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