Open Access@KRIBBDivision of A.I. & Biomedical ResearchImmunotherapy Research Center1. Journal Articles
VDUP1 is required for the development of natural killer cells
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- Title
- VDUP1 is required for the development of natural killer cells
- Author(s)
- Kee Nyung Lee; H S Kang; Jun Ho Jeon; E M Kim; Suk Ran Yoon; HyunKeun Song; Chil Youl Lyu; Z H Piao; Sun-Uk Kim; Y H Han; S S Song; Y H Lee; K S Song; Yong Man Kim; Dae Yeul Yu; In Pyo Choi
- Bibliographic Citation
- Immunity, vol. 22, no. 2, pp. 195-208
- Publication Year
- 2005
- Abstract
- Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.
- ISSN
- 1074-7613
- Publisher
- Elsevier-Cell Press
- Full Text Link
- http://dx.doi.org/10.1016/j.immuni.2004.12.012
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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