VDUP1 is required for the development of natural killer cells

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Title
VDUP1 is required for the development of natural killer cells
Author(s)
Kee Nyung Lee; H S Kang; Jun Ho Jeon; E M Kim; Suk Ran Yoon; HyunKeun Song; Chil Youl Lyu; Z H Piao; Sun-Uk Kim; Y H Han; S S Song; Y H Lee; K S Song; Yong Man Kim; Dae Yeul Yu; In Pyo Choi
Bibliographic Citation
Immunity, vol. 22, no. 2, pp. 195-208
Publication Year
2005
Abstract
Vitamin D3 upregulated protein 1 (VDUP1) is a stress-response gene that is upregulated by 1,25(OH)2D3 in tumor cells. The in vivo roles of VDUP1 were investigated by producing mice lacking VDUP1 (VDUP1-/- mice). VDUP1-/- mice showed minimal changes in the development of T and B cells, but there was a profound reduction in the numbers of natural killer (NK) cells. As well, these mice showed decreased NK activity. In the VDUP1-/- mice, the expression of CD122 was reduced, demonstrating that VDUP1 is required for CD122 expression and NK maturation. In addition, severe lymphoid hyperplasia in the small intestine was observed in VDUP1-/- mice. Taken together, these results suggest that VDUP1 is a critical factor for the development and function of NK cells in vivo.
ISSN
1074-7613
Publisher
Elsevier-Cell Press
DOI
http://dx.doi.org/10.1016/j.immuni.2004.12.012
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
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