Varied patterns of DNA methylation change between different satellite regions in bovine preimplantation development

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Title
Varied patterns of DNA methylation change between different satellite regions in bovine preimplantation development
Author(s)
Yong-Kook Kang; H J Lee; Jung Jae Shim; SeungEun Yeo; Seok Ho Kim; Deog Bon Koo; Kyung Kwang Lee; Z Beyhan; N L First; Yong Mahn Han
Bibliographic Citation
Molecular Reproduction and Development, vol. 71, no. 1, pp. 29-35
Publication Year
2005
Abstract
Global reduction of DNA methylation, a part of genome reprogramming processes, occurs in a gradual manner until before implantation and is recognized as a conserved process in mammals. Here, we reported that in bovine, satellite regions exhibited varied patterns of methylation changes when one-cell egg advanced to the blastocyst; a maintenance methylation was observed in satellite I sequences, a decrease in alpha satellites, and an increase in satellite II regions. Cloned embryos exhibited similar changes for DNA methylation in the satellite I and alpha. We also observed that the satellite I and α sequences were methylated more in inner cell mass region of the blastocyst whereas the satellite II showed selective demethylation in this region. Together, these findings point that individual satellite sequences carry their own methylation patterns under the pressure of global demethylation, suggesting that local methylation control system acts on the satellite regions in early bovine embryos.
Keyword
bovinedemethylationDNA methylationpreimplantation embryosatellite sequences
ISSN
1040-452X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/mrd.20249
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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