The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana

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Title
The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana
Author(s)
N T Dat; X F Cai; Mun Chual Rho; Hyun Sun Lee; K Bae; Y H Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 2, pp. 164-168
Publication Year
2005
Abstract
The EtOAc extract of Youngia koidzumiana significantly inhibited the diacylglycerol acyltrans-ferase (DGAT) from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of nine compounds, the structures of which were established using physicochemical and spectral data. of the isolated compounds, oleanolic acid (2), methyl ursolate (7) and corosolic aicd (8) inhibited DGAT, with IC50 values of 31.7, 26.4, and 44.3 μM, respectively. However, sesquiterpenoids showed only weak inhibitory effects toward DGAT.
Keyword
brachynereolidecorosolic acidcrepidiaside Cdiacylglycerol acyltransferasegermanicol acetateixerin Ymethyl ursolateyoungia koidzumiana
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/bf02977708
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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