Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase

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Title
Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase
Author(s)
Hyun Mi Oh; Byoung-Mog Kwon; N I Baek; S H Kim; I S Chung; M H Park; H W Park; J H Lee; H W Park; E J Kim; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 28, no. 2, pp. 169-171
Publication Year
2005
Abstract
The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 μM.
Keyword
FPTaseIsorhamnetinPersicaria thunbergii
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/BF02977709
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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