Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase
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- Title
- Inhibitory activity of isorhamnetin from Persicaria thunbergii on farnesyl protein transferase
- Author(s)
- Hyun Mi Oh; Byoung-Mog Kwon; N I Baek; S H Kim; I S Chung; M H Park; H W Park; J H Lee; H W Park; E J Kim; D K Kim
- Bibliographic Citation
- Archives of Pharmacal Research, vol. 28, no. 2, pp. 169-171
- Publication Year
- 2005
- Abstract
- The methanolic extract of the aerial parts of Persicaria thunbergii was found to show inhibitory activity on Farnesyl Protein Transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of isorhamnetin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of isorhamnetin was 37.5 μM.
- ISSN
- 0253-6269
- Publisher
- Pharmaceutical Soc Korea
- Full Text Link
- http://dx.doi.org/10.1007/BF02977709
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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