Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng

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Title
Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng
Author(s)
Mun Chual RhoHyun Sun LeeSeung Woong Lee; Jong Sun Chang; Oh Eok Kwon; Mi Yeon Chung; Young Kook Kim
Bibliographic Citation
Journal of Agricultural and Food Chemistry, vol. 53, no. 4, pp. 919-922
Publication Year
2005
Abstract
Acyl-CoA: cholesterol acyltransferase (ACAT), which plays a role in the absorption, storage, and production of cholesterol, has been explored as a potential target for pharmacological intervention of hyperlipidemia and atherosclerotic disease. In our search for ACAT inhibitors from natural sources, the petroleum ether extract of Panax ginseng showed moderate inhibition of ACAT enzyme from rat liver microsomes. Bioactivity-guided fractionations led to the isolation of one new polyacetylenic compound, (9R,10S)-epoxy-16-heptadecene-4, 6-diyne-3-one (1), in addition to the previously reported polyacetylenic compounds 2 and 3. Their chemical structures were elucidated on the basis of spectroscopic evidence (UV, IR, NMR, and MS). The compounds 1, 2, and 3 showed significant ACAT inhibition with IC50 values of 35, 47, and 21 μM, respectively.
Keyword
Acyl-CoA: cholesterol acyltransferase (ACAT)AtherosclerosisCholesteryl esterPanax ginsengPolyacetylenes
ISSN
0021-8561
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/jf040370x
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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