Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis

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Title
Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis
Author(s)
Seung Woong Lee; Hyun Sun Lee; Jung Yeon Nam; Oh Eok Kwon; Jin Ah Baek; Jong Sun Chang; Mun Chual Rho; Young Kook Kim
Bibliographic Citation
Journal of Ethnopharmacology, vol. 97, no. 3, pp. 515-519
Publication Year
2005
Abstract
The accumulation of circulating monocytes in the arterial wall is an early in atherosclerotic plaque formation. Monocyte chemoattractant protein-1 (MCP-1) promotes the migration of monocytes and would play a role in the development of atherosclerotic lesions. Searching for inhibitors of MCP-1-induced cell migration from natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae). On the basis of spectral evidence, the structure of active compound was identified as kurarinone. It inhibited the migration of THP-1 cells induced by MCP-1 with IC50 value of 19.2 μg/mL. In addition, it inhibited the binding of MCP-1 to THP-1 cells and phosphorylation of p42/44 MARK.
Keyword
Active-guided fractionationsCC chemokine receptor 2KurarinoneMonocyte chemoattractant protein-1Sophora flavescens Ait
ISSN
0378-8741
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jep.2004.12.006
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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