The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells

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Title
The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells
Author(s)
Y Yang; Jeong-Hyung Lee; Kun Yong Kim; H K Song; Jae Kwang Kim; Suk Ran Yoon; D Cho; K S Song; Y H Lee; In Pyo Choi
Bibliographic Citation
Cancer Letters, vol. 221, no. 2, pp. 191-200
Publication Year
2005
Abstract
As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.
Keyword
9-27IFN-γinvasionnatural killer cell
ISSN
0304-3835
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.canlet.2004.08.022
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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